Late Cardiac Effects of Therapy for Hodgkin Lymphoma

Hodgkin lymphoma (HL) is a leading cause of cancer among adolescents, and is often cured with chemotherapy alone or in combination with radiation therapy. Awareness of potential adverse cardiovascular sequelae due to therapy is crucial. Radiation-induced heart disease can affect cardiovascular structures in the radiation field, and risks of cardiovascular damage can be further increased due to exposure to anthracycline chemotherapy. This review provides a broad overview of the etiology, clinical presentation, surveillance and clinical challenges associated with late cardiotoxicity in HL survivors.